Abstract Search

ea0026p338 | Obesity | ECE2011

Glimepiride improves insulin sensitivity in oxidative skeletal muscle of obese rats: possible association between GLUT4 and SUR2A expressions

Felipe dos Santos Ferreira Marques M F S F M , Cristina Tieko Mori R C T M , Mitiko Okamoto M M O , Fabres Machado U F M

Studies have demonstrated that ATP-sensitive potassium channel (KATP) subunits SUR2A (sulfonylurea receptor) and KIR6.2 are involved in glucose uptake into skeletal muscle. It is known that the glucose transporter 4 (GLUT4) expression is highest in oxidative type I fibers, pointing out the important role of oxidative muscles as glucose uptakes. Considering these aspects the aim of this study was to investigate whether KATP channel can influence glucose uptake in oxidative musc...

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ea0026p735 | Diabetes (epidemiology, pathophysiology) | ECE2011

Insulin restores salivary secretion in diabetic rats: involvement of Na+/glucose cotransporter SGLT1

Sabino-Silva R , Campello R S , Nakamura H K , Freitas H S , Okamoto M M , Mori R C , Machado U F

Introduction: Considering the high capacity of water transport of Na+/glucose cotransporter SGLT1, the aim of this study was to investigate the potential role the SGLT1 in luminal membrane of ductal cells of salivary glands upon the non-stimulated salivary secretion of diabetic rats. The present study also investigates the presence of glucose transporter GLUT1 in salivary glands of rats.Methods: Non-stimulated salivary secretion and SGLT1/GLUT1 protein (...

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Endocrine Abstracts

Glimepiride improves insulin sensitivity in oxidative skeletal muscle of obese rats: possible association between GLUT4 and SUR2A expressions

Insulin restores salivary secretion in diabetic rats: involvement of Na+/glucose cotransporter SGLT1

BiosciAbstracts